Humana Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments, Volume 2 (Springer Protocols Handbooks)

From the Back Cover The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries.  Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system.  Volume 2 examines global cerebral ischemia, focal cerebral ischemia, and neonatal hypoxia-ischemia, as well as intensive sections covering traumatic brain injury and spinal cord injury.  Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used. Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments. Product Description 1. Introduction (Parts I-III) R. Anne Stetler and Miguel A. Perez-PinzonPart I: Global Cerebral Ischemia (GCI)2. Morphological Assessments of Global Cerebral Ischemia: Viable Cells Peiying Li3. Morphological Assessments of Global Cerebral Ischemia: Degenerated Cells Peiying Li4. Morphological Assessments of Global Cerebral Ischemia: Electron Microscopy Irina S. Balan, Tibor Kristian, Chunli Liu, Andrew J. Saladino, and Bingren Hu5. Biochemical and Molecular Biological Assessments of Global Cerebral Ischemia: mRNA R. Anne Stetler and Yu Gan6. Biochemical and Molecular Biological Assessments of Global Cerebral Ischemia: Protein Yu Gan and R. Anne Stetler7. Neurobehavioral Assessments of Global Cerebral Ischemia Pinar Kendigelen, Dandan Sun, and Pelin Cengiz8. Assessment of Neurogenesis in the Dentate Gyrus after Global or Focal Ischemia Wei Liu and Jialing LiuPart II: Focal Cerebral Ischemia (FCI)9. Infarct Measurement in Focal Cerebral Ischemia: TTC Staining Feng Zhang and Jun Chen10. Morphological Assessments of Focal Cerebral Ischemia: White Matter Injury Feng Zhang and Lyanne C. Schlichter11. Blood Flow Reduction: Laser Doppler, 14C-IAP Feng Zhang, Steven H. Graham, and Jun Chen12. Biochemical and Molecular Biological Assessments of Focal Cerebral Ischemia: mRNA and MicroRNA Yu Gan and R. Anne Stetler13. Biochemical and Molecular Biological Assessments of Focal Cerebral Ischemia: Protein R. Anne Stetler and Yu Gan14. Assessments of Inflammation After Focal Cerebral Ischemia Xiaoming Hu and Jun Chen15. Neurobehavioral Assessments of Focal Cerebral Ischemia: Sensorimotor Deficit Yejie Shi and Dandan Sun16. Neurobehavioral Assessments of Focal Cerebral Ischemia: Cognitive Deficit Yejie Shi and Dandan Sun17. Assessment of Neurogenesis in Models of Focal Cerebral Ischemia Feng-Yan Sun, Xiao Sun, Ji-Jiang Wang, Qiu-Wan Zhang, and Yong-Quan Wang18. Assessment of Angiogenesis in Models of Focal Cerebral Ischemia Hong Shi, Yanqin Gao, and Weimin LiangPart III: Neonatal Hypoxia-Ischemia (NHI)19. Morphological Assessments of Neonatal Hypoxia-Ischemia: In Situ Cell Degeneration Changlian Zhu and Klas Blomgren20. Morphological Assessments of Neonatal Hypoxia-Ischemia: White Matter Injury Dianer Yang and Chia-Yi Kuan21. Biochemical and Molecular Biological Assessments of Neonatal Hypoxia-Ischemia: Cell Signaling Changlian Zhu and Klas Blomgren22. Biochemical and Molecular Biological Assessments of Neonatal Hypoxia-Ischemia: Inflammation Xiaoming Hu and Jun Chen23. Neurobehavioral Assessments