Optimization in Drug Discovery (Methods in Pharmacology and Toxicology) - Image 1

Price loading...

Humana Optimization in Drug Discovery (Methods in Pharmacology and Toxicology)

Name: Optimization in Drug Discovery (Methods in Pharmacology and Toxicology)
Brand: Humana

Pharmacy - Dispensing

Price History & Forecast

No Price Data Available

Price history will appear here once data is collected from Amazon.

Price Distribution

No price data available for histogram

Description

Recent analyses of drug attrition rates reveal that a significant number of drug candidates fail in the later stage of clinical development owing to absorption, distribution, metabolism, elimination (ADME), and toxicity issues. Lead optimization in drug discovery, a process attempting to uncover and correct these defects of drug candidates, is highly beneficial in lowering the cost and time to develop therapeutic drugs by reducing drug candidate failures in development. At present, parallel synthesis combining with high-throughput screening has made it easier to generate highly potent compounds (i. e. , hits). However, to be a potential drug, a hit must have drug-like characteristics in addition to potency, which include optimal physicochemical properties, reasonable ph- macokinetic parameters, and good safety profiles. Therefore, research tools must be available in drug discovery to rapidly screen for compounds with favorable drug-like properties, and thus adequate resources can be directed to projects with high potential. Optimization in Drug Discovery: In Vitro Methods is a compilation of detailed experimental protocols necessary for setting up a variety of assays important in compound evaluation. A total of 25 chapters, contributed by many experts in their research areas, cover a wide spectrum of subjects including physicochemical properties, abso- tion, plasma binding, metabolism, drug interactions, and toxicity. A good pharmacokinetic profile has long been recognized as an imp- tant drug-like characteristic. Pharmacokinetic parameters are affected by many properties of drug molecules such as physicochemical nature, abso- tion, metabolic stability, and so on.

Product Specifications

Brand: Humana
Format: paperback
ASIN: 1617374997
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Allied Health Professions > Pharmacy - Dispensing
Domain: Amazon UK
Release Date: 09 November 2010
Listed Since: 11 July 2010

Barcode

No barcode data available

Humana Optimization in Drug Discovery (Methods in Pharmacology and Toxicology)

Price History & Forecast

No Price Data Available

Price Distribution

Description

Product Specifications

Barcode

Similar Products You Might Like

Humana Optimization in Drug Discovery: In Vitro Methods Book

Optimization in Drug Discovery: In Vitro Methods (Methods in Pharmacology and Toxicology)

Translational ADMET for Drug Therapy: Principles, Methods, and Pharmaceutical Applications

Putting Pharmacokinetics and Pharmacodynamics to Work in Drug Discovery: A Practical Guide for Pharmaceutical Scientists

Optimizing the "Drug-Like" Properties of Leads in Drug Discovery: IV (Biotechnology: Pharmaceutical Aspects, IV)

Drug-Like Properties: Concepts, Structure Design and Methods from Adme to Toxicity Optimization

Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology (Wiley Series in Drug Discovery and Development)

Humana Cytochrome P450: In Vitro Methods and Protocols Book

Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery (Methods in Pharmacology and Toxicology)

Basic Principles of Drug Discovery and Development

Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists

Lead Optimization for Medicinal Chemists: Pharmacokinetic Properties of Functional Groups and Organic Compounds

Introduction to Drug Disposition and Pharmacokinetics

Pharmacokinetics and Metabolism in Drug Design (Methods & Principles in Medicinal Chemistry)

Attrition in the Pharmaceutical Industry: Reasons, Implications, and Pathways Forward

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics (Cancer Drug Discovery and Development)

Methods for Stability Testing of Pharmaceuticals (Methods in Pharmacology and Toxicology)

High-Throughput Lead Optimization in Drug Discovery: 3 (Critical Reviews in Combinatorial Chemistry)

Drug Metabolism and Pharmacokinetics Quick Guide

ADME Processes in Pharmaceutical Sciences: Dosage, Design, and Pharmacotherapy Success

Drug Metabolism and Pharmacokinetics: Frontiers, Strategies, and Applications

Drugs and a Methodological Compendium: From bench to bedside

Pharmacokinetic Challenges in Drug Discovery: 37 (Ernst Schering Foundation Symposium Proceedings, 37)

Drug Metabolism in Drug Design and Development: Basic Concepts and Practice