£74.99

Chronicle Books Glycobiology Research Trends

Name: Glycobiology Research Trends
Brand: Chronicle Books
Price: 74.99 GBP
Availability: InStock

Biochemistry

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Description

Glycobiology is the study of the structure, biosynthesis and biology of saccharides that are widely distributed in nature and are essential components of all living things. This field combines expertise in both carbohydrate biochemistry and molecular biology. The ABC drug transporter, P glycoprotein or MDR1 is one such example discussed in this book. The relationship of glycosphingolipid (GSL) biosynthesis to the Pgp-mediated multiple drug resistance phenotype, and the role of MDR1 in lipid biosynthesis in particular is evaluated. The structure and activities of natural complex polysaccharides are also analysed. Specifically, heparin (Hep) as an anticoagulant and antithrombotic (macro)molecule and CS in the treatment of osteoarthritis is reviewed, and the GAG structure-function relationship, which has led to the discovery of novel drugs for the possible treatment of some serious diseases. The gene targeting analyses of certain enzymes, which revealed that the HNK-1 carbohydrate plays important roles in synaptic plasticity and memory function, is described as well. Recent work on the topic "protein-specific glycosylation" is highlighted also, focusing on the primary structure of a protein which directly exerts a cis-control of the glycosylation event.

Product Specifications

Brand: Chronicle Books
Format: hardcover
ASIN: 1606928414
Category: Books > Subjects > Science, Nature & Maths > Biological Sciences > Biochemistry
Domain: Amazon UK
Release Date: 30 July 2009
Listed Since: 11 December 2008

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Chronicle Books Glycobiology Research Trends

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