£52.51

Progress in DNA Damage Research

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£53 today · usual range £13–£62 · best ever £13

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Price History & Forecast

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Last 44 days • 44 data points (No recent data available)

Historical
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£61.64 £8.18 £19.84 £31.51 £43.17 £54.84 £66.50 19 March 2026 29 March 2026 09 April 2026 20 April 2026 01 May 2026

Price Distribution

Price distribution over 44 days • 10 price levels

Days at Price
Current Price
1 day 14 days 2 days 11 days 2 days 2 days 2 days 2 days 4 days · current 4 days 0 4 7 11 14 £13 £14 £22 £26 £27 £29 £37 £46 £53 £62 Days at Price

Price Analysis

Most common price: £14 (14 days, 31.8%)

Price range: £13 - £62

Price levels: 10 different prices over 44 days

Description

This book presents the latest research on DNA damage, which due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. While this constitutes only 0.000165% of the human genome's approximately 6 billion bases (3 billion base pairs), unrepaired lesions in critical genes (such as tumour suppresser genes) can impede a cell's ability to carry out its function and appreciably increase the likelihood of tumour formation. The vast majority of DNA damage affects the primary structure of the double helix; that is, the bases themselves are chemically modified. These modifications can in turn disrupt the molecules' regular helical structure by introducing non-native chemical bonds or bulky adducts that do not fit in the standard double helix. Unlike proteins and RNA, DNA usually lacks tertiary structure and therefore damage or disturbance does not occur at that level. DNA is, however, supercoiled and wound around "packaging" proteins called histones (in eukaryotes), and both superstructures are vulnerable to the effects of DNA damage.

Product Specifications

Format
hardcover
Domain
Amazon UK
Release Date
01 October 2008
Listed Since
28 March 2008

Barcode

No barcode data available

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