£20.66

New Research on DNA Damage

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£107.50 £0.37 £23.74 £47.12 £70.49 £93.87 £117.24 09 June 2024 15 November 2024 24 April 2025 30 September 2025 09 March 2026

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Description

DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. While this constitutes only 0.000165% of the human genome's approximately 6 billion bases (3 billion base pairs), unrepaired lesions in critical genes (such as tumour suppresser genes) can impede a cell's ability to carry out its function and appreciably increase the likelihood of tumour formation. The vast majority of DNA damage affects the primary structure of the double helix; that is, the bases themselves are chemically modified. These modifications can in turn disrupt the molecules' regular helical structure by introducing non-native chemical bonds or bulky adducts that do not fit in the standard double helix. Unlike proteins and RNA, DNA usually lacks tertiary structure and therefore damage or disturbance does not occur at that level. DNA is, however, supercoiled and wound around "packaging" proteins called histones (in eukaryotes), and both superstructures are vulnerable to the effects of DNA damage. This book presents the latest research in the field.

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Product Specifications

Format
hardcover
Domain
Amazon UK
Release Date
01 April 2009
Listed Since
28 March 2008

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