Origin and Evolution of Telomeres (Molecular Biology Intelligence Unit) - Image 1

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CRC Press Origin and Evolution of Telomeres (Molecular Biology Intelligence Unit)

Name: Origin and Evolution of Telomeres (Molecular Biology Intelligence Unit)
Brand: CRC Press
Price: 160.0 GBP
Availability: InStock

Immunology

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Description

Linear chromosomes represent an evolutionary innovation associated with the origin of eukaryotic cells. This book describes how linear chromosomes and primordial pathways for maintaining their terminal structures, telomeres, emerged in early eukaryotes. Telomeres, derived from the Greek meaning terminal part, were first described by Hermann Muller in 1938. Telomeres are specialized structures that comprise the ends of linear chromosomes in eukaryotes. Linearity is crucial for chromosome pairing during meiosis and sexual reproduction. Inspired by Dobzhansky's dictum that "nothing in biology makes sense except in the light of evolution", this book brings together information about the origin and evolution of telomeres, their functions and the consequences of eukaryotic linearity which is an essential prerequisite of meiotic cell division and sexual reproduction. Selective pressure toward linearization must have been associated with the emergence of robust and redundant mechanisms for the maintenance of telomeres. These pathways comprise a molecular clock involved in cell senescence, carcinogenesis and immortalization.

Product Specifications

Brand: CRC Press
Format: Hardcover
ASIN: 1587063093
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Diseases & Disorders > Immunology
Domain: Amazon UK
Release Date: 26 May 2008
Listed Since: 17 August 2012

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CRC Press Origin and Evolution of Telomeres (Molecular Biology Intelligence Unit)

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