Springer Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases (Physiology in Health and Disease)

Only recently have we begun to appreciate the role of microbiome in health and disease. Environmental factors and change of life style including diet significantly shape human microbiome that in turn appears to modify gut barrier function affecting nutrient & electrolyte absorption and inflammation. Approaches that can reverse the gut dysbiosis represent as reasonable and novel strategies for restoring the balance between host and microbes. In the book, we offer summary and discussion on the advances in understanding of pathophysiological mechanisms of microbial host interactions in human diseases. We will not only discuss intestinal bacterial community, but also viruses, fungi and oral microbiome. Microbiome studies will facilitate diagnosis, functional studies, drug development and personalized medicine. Thus, this book will further highlight the microbiome in the context of health and disease, focusing on mechanistic concepts that underlie the complex relationships between host and microbes. Review “This is a stellar contribution to the medical field. It addresses the rapidly expanding and evolving understanding in an area of human physiology that is currently of intense medical interest. Each chapter clearly shows that work in this field has the potential of producing watershed advances in human medicine. … This book is especially valuable to pediatricians, but should be read by all practicing physicians, medical students, and researchers working in GI physiology and disease.” (David R. Bell, Doody's Book Reviews, July, 2018) From the Back Cover Only recently have we begun to appreciate the role of microbiome in health and disease. Environmental factors and change of life style including diet significantly shape human microbiome that in turn appears to modify gut barrier function affecting nutrient & electrolyte absorption and inflammation. Approaches that can reverse the gut dysbiosis represent as reasonable and novel strategies for restoring the balance between host and microbes. In the book, we offer summary and discussion on the advances in understanding of pathophysiological mechanisms of microbial host interactions in human diseases. We will not only discuss intestinal bacterial community, but also viruses, fungi and oral microbiome. Microbiome studies will facilitate diagnosis, functional studies, drug development and personalized medicine. Thus, this book will further highlight the microbiome in the context of health and disease, focusing on mechanistic concepts that underlie the complex relationships between host and microbes. About the Author Dr. Jun Sun is a tenured Associate Professor at the University of Illinois at Chicago (UIC), Chicago, U.S.A. She is a Fellow of American Gastroenterological Association (AGAF). Her research interests are host-microbiome interactions in inflammation and cancer. Her key achievements include 1) characterization of the role of vitamin D receptor in regulation of gut microbiome in intestinal homeostasis and inflammation; 2) identification of dysbiosis and gut dysfunction in Amyotrophic Lateral Sclerosis (ALS); 3) identification of the role of gut bacteria in regulating intestinal stem cells, and 4) identification and characterization of the Salmonella effector protein AvrA in host-bacterial interactions in infection and cancer. Dr. Sun has published over 120 scientific articles in peer-reviewed journals, including Cell Stem Cells, Nature Genetics, Gut, JBC, American Journal of Pathology, American Journal of Physiology-GI. She is on the editorial board of more than 10 peer-reviewed international scientific journals. She serves on several study sections e.g. NIH, American Cancer Society, and other national and international research foundations. Her research is supported by the NIH, DOD, and other industry sponsored awards. Using several models including transgenic mice, germ-free animals, and human samples, her lab