Humana Perinatal and Prenatal Disorders (Oxidative Stress in Applied Basic Research and Clinical Practice)

This authoritative volume describes the role of free radicals and antioxidants in prenatal and perinatal disorders currently explored in clinical and pre-clinical trials. In twenty-two inclusive chapters, the book covers the gamut of oxidative stress and its relation to a variety of factors, including fertility, metabolism, redox biomarkers, antioxidant defense and protection, gene polymorphisms, angiogenesis, cell signaling, mutations and oxidative damage involving lipids, proteins and nucleic acids, membrane trafficking, inflammation, mitochondrial dysfunction, alterations in immunological function, hypoxia, and post-natal stressors. This comprehensive source will keep clinicians and research scientists up-to-date on translational research into medical applications. Perinatal and Prenatal Disorders is a significant addition to the well-known Oxidative Stress in Applied Basic Research and Clinical Practice series. Review “This is a compilation of 22 relatively independent reviews of topics in the field of oxidative stress during the perinatal period. … The audience is both researchers and sophisticated clinicians in the area of perinatal medicine. … It editors and authors are well-known researchers and this book should help focus new research into the toxic effects of oxygen radical species on the fragile fetus and neonate as well as the care of this vulnerable population.” (Jay P. Goldsmith, Doody’s Book Reviews, March, 2015) “This volume reviews in 22 chapters the role of oxidative injury to early embryonic development and possible consequences. … A useful book for neonatologists.” (Pediatric Endocrinology Reviews (PER), Vol. 12 (4), 2015) From the Back Cover This authoritative volume describes the role of free radicals and antioxidants in prenatal and perinatal disorders currently explored in clinical and pre-clinical trials. In twenty-two inclusive chapters, the book covers the gamut of oxidative stress and its relation to a variety of factors, including fertility, metabolism, redox biomarkers, antioxidant defense and protection, gene polymorphisms, angiogenesis, cell signaling, mutations and oxidative damage involving lipids, proteins and nucleic acids, membrane trafficking, inflammation, mitochondrial dysfunction, alterations in immunological function, hypoxia, and post-natal stressors. This comprehensive source will keep clinicians and research scientists up-to-date on translational research into medical applications. Perinatal and Prenatal Disorders is a significant addition to the well-known Oxidative Stress in Applied Basic Research and Clinical Practice series. About the Author Phyllis A. Dennery, MD, FAAP is a professor of pediatrics at the University of Pennsylvania School of Medicine in Philadelphia, Pennsylvania. She holds the Werner and Gertrude Henle endowed chair in pediatrics at The Children’s Hospital of Philadelphia (CHOP). She is chief of the Division of Neonatology and Newborn Services at CHOP and the University of Pennsylvania Health System. Dr. Dennery obtained her medical degree from Howard University in Washington, D.C., and completed a residency in pediatrics at Children’s Hospital National Medical Center in Washington, D.C., and a fellowship in neonatology at Case Western Reserve University (Rainbow Babies and Children’s Hospital) in Cleveland, Ohio. Dr. Dennery’s research interests are in neonatal oxidative stress, lung chronobiology, and circadian gene regulation; her clinical interests are in neonatal jaundice, bronchopulmonary dysplasia, and the long-term consequences of prematurity. Professor Giuseppe Buonocore is professor and chairman of the School of Specialization in Pediatrics & Neonatology in the Department of Molecular and Developmental Medicine, University of Siena, Tuscany. He is internationally recognized for his research on hyperbilirubinemia, biomarkers of oxidative stress, free radical–related diseases of the newborn,