Springer Epigenetics and Complex Traits

Product Description This book covers basic epigenetic phenomena; interplay of epigenetic and genetic factors; the influences of epigenetic factors on inheritance; relationships between epigenetic and genetic changes in human disease and statistical analysis of epigenetic effects. From the Back Cover Epigenetics and Complex Traits provides an overview of basic epigenetic phenomena that influence transmission of genetic traits, including the pivotal roles of epigenetic factors in genome integrity, genetic transmission and phenotypic variation at critical developmental points, interactions between epigenetic marks and genetic variation, as well as a detailed examination of how epigenetic considerations can alter interpretation and analysis of risks for complex traits.   Included in this book are several overviews of the impact of inter-individual variation in epigenetic states, from major changes that cause congenital developmental defects to subtle changes and their impact on complex traits. In addition, there are chapters examining the relationship between epigenetic changes and genetic changes in human disease, methods for statistical analysis of epigenetics effects in human disease genetic studies or in population genetics, and a consideration of how epigenetics influences inheritance and analysis of inheritance.   Epigenetics and Complex Traits is a  resource for those who are working in mammalian genetics or analysis of human genetic data and are interested in the impact of epigenetics on inheritance.