£110.54

Springer Molecular Pathogenesis of Colorectal Cancer

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£111 today · all-time low £110 (Feb 2026) · usually £113

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£113.93 £109.30 £110.31 £111.32 £112.33 £113.34 £114.35 18 February 2026 12 March 2026 03 April 2026 25 April 2026 18 May 2026

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Most common price: £112 (65 days, 72.2%)

Price range: £110 - £114

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Description

Product Description This book identifies and characterizes targetable oncogenic pathways in colorectal cancer. It explores the current and future prospects for targeting these pathways therapeutically and presents emerging technologies for identifying new cancer related genes. From the Back Cover For more than two decades, colorectal cancer has served as the paradigm for the cooperative activity of oncogenes and tumor suppressor genes in cancer initiation and progression. The depth of molecular characterization for this disease is unparalleled, with specific mutations correlated to each histologic stage of progression from normal colon to malignant colorectal cancer. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. This book explores the past, present, and future of colorectal cancer genetics, with particular emphasis on how knowledge of the molecular pathogenesis of the disease leads to the development of novel therapeutic strategies. Individual chapters discuss general topics, such as genomic instability and inflammation, or else specific pathways, for example RAS, PI3K, and TGF-b, that play a role in colorectal cancer progression.

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