Taurine 4: Taurine and Excitable Tissues: 483 (Advances in Experimental Medicine and Biology, 483) - Image 1

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Springer Taurine 4: Taurine and Excitable Tissues: 483 (Advances in Experimental Medicine and Biology, 483)

Name: Taurine 4: Taurine and Excitable Tissues: 483 (Advances in Experimental Medicine and Biology, 483)
Brand: Springer
Price: 144.77 GBP
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Neurology & Clinical Neurophysiology

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Mitochondria from mammalian tissues possess an elaborate system for 2+ 2+ transporting Ca across their inner membrane which consists of Ca import, 2+ via the Ca uniporter, in response to the mitochondrial membrane 2+ + potential ?? and of Ca release by an antiport system in exchange for H + 9,23 or Na (see Fig. l) . Because the uniporter is dependent upon the external 2+ 2+ 2+ 2+ Ca concentration ([Ca ]), mitochondria accumulate Ca until the [Ca ] o o 2+ decreases to the level at which the uniporter activity balances the Ca efflux. 2+ The [Ca ] at which the uniporter and efflux activities are equal is defined o the “setpoint” andcorresponds to values between 0.3-3µM. 2+ Figure 1. The Ca transport system of the inner membrane of mammalian mitochondria. U, + 2+ + + uniporter. I, Na -independent efflux mechanism or Ca /2H exchanger. D, Na -dependent 2+ + efflux mechanism or Ca /2Na exchanger. PTP, permeability transition pore. FP, 11 flavoprotein. ?? membrane potential. ? pH gradient. Adapted from .

Product Specifications

Brand: Springer
Format: paperback
ASIN: 1475773420
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Neurology & Clinical Neurophysiology
Domain: Amazon UK
Publication Date: 12 March 2013
Listed Since: 20 September 2013

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Springer Taurine 4: Taurine and Excitable Tissues: 483 (Advances in Experimental Medicine and Biology, 483)

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