Humana Chemokines in Disease: Biology and Clinical Research (Contemporary Immunology)

Caroline Hébert and a panel of key experimentalists and clinical investigators comprehensively review the state-of-the-art in the chemokine field, ranging from the effects of chemokines and their receptors in retroviral infections, to their role in inflammation, angiogenesis/angiostasis, and tumor cell biology. The book examines in detail fifteen recently identified chemokines and elucidates the role of chemokine function in vivo from animal experiments. Animal models are also used to explore how chemokines operate in a variety of chronic and acute inflammatory diseases and in noninflammatory processes. A detailed review of the emerging role of chemokines in viral biology is also presented, with emphasis on HIV biology and novel therapeutic possibilities. Chemokines in Disease: Biology and Clinical Research summarizes the rapidly expanding knowledge of a dazzling array of chemokines and provides fresh insights into the development of powerful new drugs for treating a wide spectrum of diseases. Review ". . . contains a masterful review of some of the most exciting areas in the chemokine field, ranging from the effects of chemokines and their receptors in retroviral infections, to angiogenesis/antiangiogenesis, to inflammation, to asthma, to transplantation, to name a few of the areas of study. :-Foreword by Peter Ward, PhD . "The editor is a recognized authority in chemokines. Knowledgeable individuals wrote the chapters. . .There is, in this one volume, a major focus on different diseases in which chemokines seem to play particularly important roles and thus the information is easily accessed. "-Doody's Health Scienc Book Review Journal "...the reader will find great interest in reading the very good reviews on the contribution of chemokines in inflammatory diseases....A very nicely documented chapter deals with the presence of chemokine receptors in the central nervous system (CNS) and illustrates the importance to further study this field during CNS related diseases such as Alzheimer's disease or multiple sclerosis....very interesting and important topics are presented in this book.... All scientists and physicians dealing with inflammatory processes should be aware of its content."- Biochimie