Purine Metabolism in Man: Biochemistry and Pharmacology of Uric Acid Metabolism: 41 (Advances in Experimental Medicine and Biology, 41) - Image 1

£77.61

Springer Purine Metabolism in Man: Biochemistry and Pharmacology of Uric Acid Metabolism: 41 (Advances in Experimental Medicine and Biology, 41)

Name: Purine Metabolism in Man: Biochemistry and Pharmacology of Uric Acid Metabolism: 41 (Advances in Experimental Medicine and Biology, 41)
Brand: Springer
Price: 77.9 GBP
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Biochemistry

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Description

Gout and urie acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of urie acid excretion, although still posing difficult problems, appears to approach clari fication.

Product Specifications

Brand: Springer
Format: paperback
ASIN: 1475714351
Category: Books > Subjects > Science, Nature & Maths > Biological Sciences > Biochemistry
Domain: Amazon UK
Release Date: 15 April 2013
Listed Since: 20 September 2013

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Springer Purine Metabolism in Man: Biochemistry and Pharmacology of Uric Acid Metabolism: 41 (Advances in Experimental Medicine and Biology, 41)

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