CRC Press Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications (Imaging in Medical Diagnosis and Therapy)

The use of small animal models in basic and preclinical sciences constitutes an integral part of testing new pharmaceutical agents prior to their application in clinical practice. New imaging and therapeutic approaches need to be tested and validated first in animals before application to humans. Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications collects the latest information about various imaging and therapeutic technologies used in preclinical research into a single source. Useful to established researchers as well as newcomers to the field, this handbook shows readers how to exploit and integrate these imaging and treatment modalities and techniques into their own research. The book first presents introductory material on small animal imaging, therapy, and research ethics. It next covers ionizing radiation and nonionizing radiation methods in small animal imaging, hybrid imaging, and imaging agents. The book then addresses therapeutic research platforms and image quantification, explaining how to ensure accurate measurements of high-quality data. It concludes with an overview of many small animal imaging and therapy applications that demonstrate the strength of the techniques in biomedical fields. Review "A great overview of current small animal imaging modalities describing their principles of operation, equipment components, and most recent applications with extremely helpful illustrations. An essential book for every biologist, chemist, and physicist involved in small animal research."―Magdalena Bazalova-Carter, PhD, Department of Physics and Astronomy, University of Victoria "… a superb, comprehensive, and very accurate depiction of the state of the art in small animal imaging technologies and applications. This is an authoritative book and invaluable source of information for all biomedical sciences and technologies students, as well as for educators, professionals, and researchers in this multidisciplinary field."―Professor George Kontaxakis, Universidad Politécnica de Madrid About the Author George C. Kagadis, PhD, FAAPM, is an associate professor of medical physics and medical informatics at the University of Patras. He also holds an adjunct assistant professor appointment at the University of Texas MD Anderson Cancer Center. He is a Greek State Scholarship Foundation grantee, a Fulbright research scholar, and a fellow of the American Association of Physicists in Medicine (AAPM). He has authored about 80 journal papers and presented at more than 20 conferences. He received his PhD in medical physics from the University of Patras. His current research interests focus on medical image processing and analysis, studies in molecular imaging, IHE, and CAD applications. Nancy L. Ford, PhD, is an assistant professor in the Department of Oral, Biological and Medical Sciences and the director of the Centre for High-Throughput Phenogenomics at the University of British Columbia. She is a full member of the AAPM and an associate editor of Medical Physics. She publishes in journals on medical physics, radiology, and dental science. She received her PhD in medical biophysics from the University of Western Ontario. Her research focuses on preclinical micro-computed tomography imaging and image-based analysis, primarily studying models of respiratory diseases, along with CBCT and MSCT for medical and dental applications. Dimitrios N. Karnabatidis, PhD, EBIR, is an associate professor of interventional radiology at the University of Patras. He is a fellow of the Cardiovascular and Interventional Radiological Society of Europe and a member of the Hellenic Radiology Society, the Hellenic Society of Interventional Radiology, and the Western Greece Radiology Society. He has been involved as a participant/principal investigator in several national/international research projects and has published 122 articles in peer-reviewed journals. He received his PhD from the School of