Gene Transfer in the Cardiovascular System: Experimental Approaches and Therapeutic Implications: 189 (Developments in Cardiovascular Medicine, 189) - Image 1

£164.60

Springer Gene Transfer in the Cardiovascular System: Experimental Approaches and Therapeutic Implications: 189 (Developments in Cardiovascular Medicine, 189)

Name: Gene Transfer in the Cardiovascular System: Experimental Approaches and Therapeutic Implications: 189 (Developments in Cardiovascular Medicine, 189)
Brand: Springer
Price: 164.6 GBP
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Cardiovascular

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Description

The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled "Artificial Self-Assembling Systems for Gene Transfer", brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their successes, viral-based systems have some geneml limitations and system-specific limitations. When employing a viml-based system, the following limitations should be considered: • size limitation of the inserted gene due to packaging constraints (e. g. adenovirus, retrovirus) . • potential tumorigenesis (e. g. retrovirus) • potential for insertional mutagenesis (greater than plasmid based systems) • potential imrnunogenicity (e. g.

Product Specifications

Brand: Springer
Format: Paperback
ASIN: 1461378818
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Cardiovascular
Domain: Amazon UK
Release Date: 12 October 2012
Listed Since: 03 March 2013

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Springer Gene Transfer in the Cardiovascular System: Experimental Approaches and Therapeutic Implications: 189 (Developments in Cardiovascular Medicine, 189)

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