CRC Press Electrical and Mechanical Sensing in Cell Membranes

Bioprocesses such as brain signaling to sound perception, muscle contraction, and blood pressure regulation all depend on our cells' ability to detect electrical & mechanical cues from the environment and neighboring cells. This book presents a coherent introduction to the physiological significance, the mechanisms, and the pathological implications of electrical and mechanical sensing. This authoritative book covers the fundamental principles and recent discoveries of new molecular sensors, as well as experimental and computational techniques used in the field. It also provides an overview on the pharmacological tools that can restore defective detection of electrical & mechanical stimuli. About the Author Francesco Tombola is associate professor in Physiology and Biophysics at the University of California, Irvine. He has been studying ion channels for over 15 years, and has experience with the identification of new channel-forming proteins and with the biophysical characterization of ion conduction pathways in membrane proteins. He has contributed to the establishment of new techniques to study ion channels, to the identification of drugs targeting ion channels, and to the discovery of new physiological functions of ion channels. His research has been funded by NIH, the American Heart Association, and the University of California, Irvine, and has been disseminated through published papers, review articles, and national and international invited lectures. He teaches nerve physiology and auditory physiology to medical students and ion channel physiology to graduate students.