Peptidomimetics in Organic and Medicinal Chemistry: The Art of Transforming Peptides in Drugs - Image 1

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Wiley Peptidomimetics in Organic and Medicinal Chemistry: The Art of Transforming Peptides in Drugs

Name: Peptidomimetics in Organic and Medicinal Chemistry: The Art of Transforming Peptides in Drugs
Brand: Wiley
Price: 98.0 GBP
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Pharmacy - Dispensing

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Description

A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.

Product Specifications

Brand: Wiley
Format: hardcover
ASIN: 1119950600
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Allied Health Professions > Pharmacy - Dispensing
Domain: Amazon UK
Release Date: 12 March 2014
Listed Since: 04 April 2011

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Wiley Peptidomimetics in Organic and Medicinal Chemistry: The Art of Transforming Peptides in Drugs

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