Intelligent Scaffolds for Advanced Bone Regeneration

Copyright © 2025 A9.com LLC or its affiliates. Published Heritage Branch, Library and Archives Canada. All rights reserved. No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the publisher, except in the case of brief quotations used in critical reviews or scholarly articles. This book is a work of academic and scientific research for Doctoral thesis as Development and Optimization of a Chitosan-Based Nanocomposite Scaffold with Magnesium-Doped Hydroxyapatite and Bioactive Agents for Enhanced Bone Augmentation. While every effort has been made to ensure the accuracy and reliability of the information presented herein, the authors and publisher accept no responsibility for any errors or omissions or for any consequences arising from the use of this material. Bone tissue engineering (BTE) integrates materials science, cellular biology, and biomedical engineering to address the challenges of regenerating bone in critical-sized defects caused by trauma, disease, or surgical resection. Traditional bone grafts face limitations such as donor site morbidity and insufficient vascularization, necessitating advanced biomimetic solutions. This research introduces a novel chitosan-based nanocomposite scaffold doped with magnesium-enriched hydroxyapatite (Mg-HA) and enhanced with bioactive agents—Icariin, Lithium Chloride, and Naringin—to improve bone augmentation. The scaffold aims to mimic the extracellular matrix (ECM) of bone, providing mechanical support, osteoinductivity, osteoconductivity, and vascularization. By leveraging advanced fabrication techniques and proposing targeted enhancements, this study seeks to increase the quality and quantity of regenerated bone, offering a sustainable alternative to conventional grafts. The research will validate the scaffold’s efficacy through in vitro and in vivo studies, with the ultimate goal of advancing clinical translation for maxillofacial and orthopedic applications. The primary aim of this research is to develop and optimize a chitosan-based nanocomposite scaffold incorporating magnesium-doped hydroxyapatite (Mg-HA) and bioactive molecules (Icariin, Lithium Chloride, and Naringin) to enhance bone augmentation.