Gene Targeting Protocols: 133 (Methods in Molecular Biology, 133) - Image 1

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Humana Gene Targeting Protocols: 133 (Methods in Molecular Biology, 133)

Name: Gene Targeting Protocols: 133 (Methods in Molecular Biology, 133)
Brand: Humana
Price: 83.2 GBP
Availability: InStock

Laboratory Medicine

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Description

The potential now exists in many experimental systems to transfer a cloned, modified gene back into the genome of the host organism. In the ideal situation, the cloned gene is returned to its homologous location in the genome and becomes inserted at the target locus. This process is a controlled means for the repair of DNA damage and ensures accurate chromosome disjunction during meiosis. The paradigm for thinking about the mechanism of this p- cess has emerged primarily from two sources: (1) The principles of reaction mechanics have come from detailed biochemical analyses of the RecA protein purified from Escherichia coli; and (2) the principles of information transfer have been derived from genetic studies carried out in bacteriophage and fungi. A compelling picture of the process of homologous pairing and DNA strand exchange has been influential in directing investigators interested in gene t- geting experiments. The ability to find and pair homologous DNA molecules enables ac- rate gene targeting and is the central phenomenon underlying genetic recombi- tion. Biochemically, the overall process can be thought of as a series of steps in a reaction pathway whereby DNA molecules are brought into homologous register, the four-stranded Holliday structure intermediate is formed, hete- duplex DNA is extended, and DNA strands are exchanged. Not much is known about the biochemical pathway leading to homologous recombination in euka- otes.

Product Specifications

Brand: Humana
Format: hardcover
ASIN: 0896033600
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Allied Health Professions > Laboratory Medicine
Domain: Amazon UK
Release Date: 23 September 1999
Listed Since: 28 December 2006

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Humana Gene Targeting Protocols: 133 (Methods in Molecular Biology, 133)

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