Cold Spring Harbor Laboratory Press Genetics of Complex Human Diseases: A Laboratory Manual

Many human diseases including Alzheimer's disease, sch izophrenia, cancer, and cardiovascular disease have complex genetics that require sophisticated analysis. Genetics of Complex Human Diseases: A Laboratory Manual brings together the tools that geneticists use to find disease genes with the genetic concepts and statistical theories that underpin these research approaches. Topics covered include basic genetics and Mendelian inheritance, statistical methods, genetic epidemiology, linkage studies, transmission disequilibrium test analysis, variance components analysis, genome-wide association studies, copy-number variation, methods for high-throughput genotyping, the complexity of RNA editing, and genetic computer programs. The book's chapters, written by leading investigators in the field, blend practical information and reviews of each topic, providing both the how and the why of complex disease analysis. Genetics of Complex Human Diseases is an important guide for anyone with an interest in human genetics or who uses genetic techniques in the study of diseases with complex inheritance. 1. Introduction Ammar Al-Chalabi and Laura Almasy 2. Statistics 101 A Primer for the Genetics of Complex Human Diseases Janet Sinsheimer 3. Linkage Analysis of Discrete Traits I.B. Borecki and J. Rice 4. Epidemiologic Considerations in Complex Disease Genetics John Gallacher 5. Variance Component Methods for Analysis of Complex Phenotypes Laura Almasy and John Blangero 6. Multiple Testing and Power Calculations in Genetic Association Studies Hon-Cheong So and Pak C. Sham 7. Introduction to Genetic Association Studies Cathryn M. Lewis and Jo Knight 8. Genome-Wide Association Studies Ammar Al-Chalabi 9. Introduction to Linkage Disequilibrium, the HapMap, and Imputation Benjamin M. Neale 10. Meta-Analysis of Genome-Wide Association Studies Paul I.W. de Bakker, Benjamin M. Neale, and Mark J. Daly 11. Gene Environment Interaction and Common Disease Ruth J.F. Loos and Nicholas J. Wareham 12. Family-Based Genetic Association Tests Eden R. Martin and Evadnie Rampersaud 13. Copy-Number Variation Dheeraj Malhatra and Jonathan Sebat 14. Oncogenomics Simon J. Furney, Gunes Gundem, and Nuria Lopez-Bigas 15. When the Genetic Code Is Not Enough How Sequence Variations Can Affect Pre-mRNA Splicing and Cause (Complex) Disease Brage Storstein Andresen and Adrian R. Krainer 16. Laboratory Methods for High-Throughput Genotyping Howard J. Edenberg and Yunlong Liu 17. Gene Set and Network Analysis for Genome-Wide Association Studies Inti Pedroso and Gerome Breen