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£116.44
Springer Molecular Genetics of Cardiac Electrophysiology: 231 (Developments in Cardiovascular Medicine, 231)
Price data last checked 47 day(s) ago - refreshing...
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Last 44 days • 44 data points (No recent data available)
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Price distribution over 44 days • 5 price levels
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Most common price: £113 (15 days, 34.1%)
Price range: £108 - £118
Price levels: 5 different prices over 44 days
Description
The molecular basis for atrial fibrillation continues to be largely unknown, and therapy remains unchanged, aimed at controlling the heart rate and preventing systemic emboli with anticoagulation. Familial atrial fibrillation is more common than previously suspected. While atrial fibrillation is commonly associated with acquired heart disease, a significant proportion of individuals have early onset without other forms of heart disease, referred to as "lone" atrial fibrillators. It is also well recognized that atrial fibrillation occurs on a reversible or functional basis, without associated structural heart disease, such as with hyperthyroidism or of atrial fibrillation following surgery. It remains to be determined what percentage in these individuals is familial or due to a genetic predisposition. Mapping the locus for familial atrial fibrillation is the first step towards the identification of the gene. Isolation of the gene and subsequent identification of the responsible molecular genetic defect should provide a point of entry into the mechanism responsible for the familial form and the common acquired forms of the disease and eventually provide more effective therapy. We know that the ionic currents responsible for the action potential of the atrium is due to multiple channel proteins as is electrical conduction throughout the atria. Analogous to the ongoing genetic studies in patients with familial long QT syndrome, it is highly likely that defects in each of these channel proteins will be manifested in familial atrial fibrillation.
Key Features
Used Book in Good Condition
Product Specifications
- Brand
- Springer
- Format
- hardcover
- ASIN
- 0792378296
- Domain
- Amazon UK
- Release Date
- 30 April 2000
- Listed Since
- 27 December 2006
Barcode
No barcode data available
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