Wiley Principles of Mass Spectrometry Applied to Biomolecules (Wiley Series on Mass Spectrometry)

An extensive compilation of articles by leading professionals, this reference explains the fundamental principles of mass spectrometry as they relate to the life sciences. Topics covered include spectroscopy, energetics and mechanisms of peptide fragmentation, electron capture dissociation, ion-ion and ion-molecule reactions, reaction dynamics, collisional activation, soft-landing, protein structure and interactions, thermochemistry, and more. The book empowers readers to develop new ways of using these techniques. Review "this is a very impressive volume, which I recommend to anyone interested in fundamental principles governing peptide and protein ion behavior in the gas phase."  ( Journal of the American Chemical Society, April 4, 2007) "...the book is well written with numerous companion figures and tables and extensive up-to-date references..."  (Journal of the American Society for Mass Spectrometry, April 2007) From the Inside Flap The principles of mass spectrometry as applied to the life sciences An extensive compilation of reviews, opinions, and applications by today's top researchers and professionals in the field, Principles of Mass Spectrometry Applied to Biomolecules presents the latest information on the basic principles of mass spectrometry as they relate to the life sciences, with special focus on the inherent challenges posed by varying degrees of biomolecular size and flexibility. Featuring the professional contributions of more than twenty-five experts from academia and industry, the text helps readers to understand how to use recent advances while recognizing and discussing challenges associated with analysis of biomolecules using mass spectrometry. Topics have been arranged into three distinct sectionsStructures and Dynamics of Gas-Phase Biomolecules; Activation, Dissociation, and Reactivity; and Thermochemistry and Energeticsand include: Spectroscopy Energetics and mechanisms of peptide fragmentation Electron capture dissociation Ion-ion and ion-molecule reactions Reaction dynamics Collisional activation Soft-landing Protein structure and interactions Thermochemistry This important work provides today's scientists and researchers with an in-depth understanding of the fundamental principles underlying the existing analytical approaches in this exciting and growing field, complete with its successes and limitations, so that they can develop new and innovative ways of using these techniques in their own work. From the Back Cover The principles of mass spectrometry as applied to the life sciences An extensive compilation of reviews, opinions, and applications by today's top researchers and professionals in the field, Principles of Mass Spectrometry Applied to Biomolecules presents the latest information on the basic principles of mass spectrometry as they relate to the life sciences, with special focus on the inherent challenges posed by varying degrees of biomolecular size and flexibility. Featuring the professional contributions of more than twenty-five experts from academia and industry, the text helps readers to understand how to use recent advances while recognizing and discussing challenges associated with analysis of biomolecules using mass spectrometry. Topics have been arranged into three distinct sectionsStructures and Dynamics of Gas-Phase Biomolecules; Activation, Dissociation, and Reactivity; and Thermochemistry and Energeticsand include: Spectroscopy Energetics and mechanisms of peptide fragmentation Electron capture dissociation Ion-ion and ion-molecule reactions Reaction dynamics Collisional activation Soft-landing Protein structure and interactions Thermochemistry This important work provides today's scientists and researchers with an in-depth understanding of the fundamental principles underlying the existing analytical approaches in this exciting and growing field, complete with its successes and limitations, so that