Wiley-Blackwell Bacterial Endotoxins: Lipopolysaccharides from Genes to Therapy (Progress in Clinical and Biological Research)

These proceedings of the Third Conference of the International Endotoxin Society cover the most recent basic and clinical research on lipopolysaccharides: the endotoxin derived from gram negative bacterial cell walls, which plays a major role in the inflammatory response to bacteria. Synopsis This monograph addresses recent findings on the molecular genetics and biosynthesis of lipopolysaccharides, their chemistry and structure, binding and processing in biological systems, nitric oxide induction, signal transduction, degradation, role in pathogenesis, and therapeutic measures. From the Back Cover Progress in Clinical and Biological Research, Volume 392 Bacterial Endotoxins Lipopolysaccharides From Genes to Therapy Proceedings of the Third Conference of the International Endotoxin Society, Held in Helsinki, Finland, August 15 18, 1994 Jack Levin, Carl R. Alving, Robert S. Munford, and Heinz Redl, Editors In the past two decades, the scope of research in the field of bacterial endotoxins has expanded dramatically. Bacterial Endotoxins: Lipopolysaccharides From Genes to Therapy contains the most recent basic and clinical work of researchers studying lipopolysaccharides (LPS), including everything from recent findings on the molecular genetics and biosynthesis of LPS, to various aspects of endotoxin tolerance. Assembling information from the work of renowned international researchers, the book is divided into ten well–organized sections, each of which includes papers representing the state of the art in LPS investigations. Specific topics covered in the text include: the structure and biosynthesis of Rhizobium leguminosarum lipid A conformation and fluidity of endotoxins as determinants of biological activity modalities of endotoxin binding to CD14 rational computer–aided design of ligands that bind endotoxin formation of a TNF synthesis inhibitor in endotoxin tolerance monophosphoryl lipid A as a prophylactic for sepsis and septic shock Bacterial Endotoxins: Lipopolysaccharides From Genes to Therapy provides a clear reflection of the vitality of the bacterial endotoxin macromolecule and its biological effects. This book will appeal to laboratory and clinical medical microbiologists, immunologists studying bacterial endotoxins, and internal medicine specialists who are treating inflammatory disease. The breadth of coverage will also make it a valuable resource for researchers within both the biotechnology and pharmaceutical fields.