Elsevier Protein Adaptations and Signal Transduction (Volume 2) (Cell and Molecular Response to Stress, Volume 2)

This volume of Cell and Molecular Responses to Stress has two broad themes: an examination of selected protein adaptations that support stress tolerance and an analysis of signal transduction systems, those critical links between the perception of stress and the activation of the coordinated metabolic responses that ensure survival. Several chapters deal with adaptive responses to environmental cold temperature and highlight novel advances in mammalian hibernation, low temperature enzyme function, cold-shock and antifreeze proteins, and freezing survival. Other chapters stretch out to explore biochemical responses to diverse stresses including water stress, mechanical stress, nutrient availability, oxygen limitation and oxidative stress. The integral roles of protein kinases, transcription factors, oxygen free radicals, and oxygen-sensitive ion channels in the detection and mediation of stress responses are explored. The multiplicity of responses is emphasized and shows us the vast potential of cells and organisms to respond to innumerable stresses, great and small, and the regulatory principles and mechanisms that are used to allow life to adapt and endure in every environment on Earth. Featuring: A discussion of new advances in understanding protein adaptations that support organismal survival of stress. State-of-the-art analysis of key components of cellular signal transduction pathways including protein kinases and calcium and the control, integration and action of signal transduction pathways in response to stresses including mechanical stress, nutrient availability, oxidative stress. Review Mason Posner ...I would strongly recommend this book to anyone interested in a current description of the molecular mechanisms that allow cells to react to stress. The chapters on kinase systems and their involvement in transduction pathways are important reading for any comparative biologist interested in stress. Any thorough analysis of stress response will need to integrate this new wealth of molecular information. Furthermore, the descriptions of how cells sense and response to diverse stresses can provide valuable insights to anyone thinking about stress response. Journal of Experimental Biology