Elsevier Neurobiology of Depression: Road to Novel Therapeutics (Neurobiology of Disease)

Neurobiology of Depression: Road to Novel Therapeutics, Second Edition provides the latest research advances, including interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the novel optogenetic techniques revolutionizing depression research. This new edition aids advanced students and researchers in their understanding of MDD, presenting chapters that explore groundbreaking topics such as the neurobiology of treatment-resistant depression, the mechanisms that make ketamine a better antidepressant, and the link between depression and Alzheimer's disease. Additionally, it covers the neurobiology of suicide in depression, the impact of psychedelics as therapy, and the unique aspects of bipolar depression. The book also examines computational models in depression, the neurobiology of psychotherapy, and the putative mechanisms of action for vagus nerve stimulation as a therapeutic approach. These additions help provide a broader and more comprehensive understanding of depression and its treatment. Features new chapters on emerging topics such as the neurobiology of suicide, the link between depression and Alzheimer's disease, and the mechanisms of action of psychedelics as therapy, offering readers the latest insights Explores major depressive disorder (MDD) within the framework of the NIMH Research Domain Criteria (RDoC) recommendations Covers a wide array of existing and potential pharmacologic and non-pharmacologic treatment options, including lifestyle adjustments, antidepressants, and emerging novel therapeutics Synthesizes discussions on the cellular and molecular mechanisms underlying depressive symptoms with clinical aspects, bridging the gap between basic neuroscience and clinical practice