Elsevier Brain Energy Metabolism in Alzheimers Disease - Part A: Volume 186 (International Review of Neurobiology, Volume 186)

Brain Energy Metabolism in Alzheimer’s Disease – Part A, published as Volume 186 of the serial International Review of Neurobiology, provides a comprehensive and up‑to‑date synthesis of molecular, cellular, and systemic mechanisms underpinning energy dysregulation in neurodegeneration, with a primary focus on Alzheimer’s disease. This volume assembles expert-led reviews exploring key metabolic pathways―from glutamate–glutamine cycling and mitochondrial bioenergetics to neurovascular coupling, circadian regulation, and gut–brain axis interactions―while also examining emerging contributors such as environmental toxins, PFAS exposure, and microplastic-induced neurotoxicity. Together, these chapters illuminate how disrupted energy homeostasis intersects with oxidative stress, inflammation, and neuronal senescence, offering new insights into disease pathophysiology and therapeutic targeting. Integrates classical and emerging perspectives on brain energy metabolism in Alzheimer’s disease Highlights the role of mitochondrial dysfunction, redox imbalance, and neuronal senescence Explores environmental and systemic modifiers, including microplastics, PFAS, and gut microbiome dysbiosis Examines neurotransmitter metabolism, particularly glutamate–glutamine cycling, across neurodegenerative disorders Addresses regulatory mechanisms such as circadian rhythms and neurovascular coupling Provides translational insights with potential therapeutic avenues, including marine-derived bioactive compounds