CRC Press Redox Regulation of Differentiation and De-differentiation: 48 (Oxidative Stress and Disease)

Product Description Cell differentiation and the development of multicellular organisms are processes of self- assembly, controlled and driven by signaling molecules and cascades including redox regulation. These reactions may have provided the energy for the first metabolic steps in the evolution of life. Today, redox modifications are established as important regulatory events in cellular functions including differentiation and development. Redox modifications of single cysteines regulate differentiation of stem cells, formation of functioning organs, and malformations, such as cancer cells. Current cancer therapy coopts redox events. Understanding differentiation and de-differentiation on a molecular level is a prerequisite for the continuing development of new medical therapies. This book summarizes the roles of redox regulation in devlopment by bringing together different concepts and comparing similarities and differences between various cell types and species. An international team of contributors presents several new aspects of redox regulated differentiation and de-differentiation, including aspects of cancer therapy. About the Author Carsten Berndt is in the Department of Neurology, Heinrich-Heine-Universität Düsseldorf. He is the author or co-author of over 50 peer revidewed scholarly publications. His research has focuesd on the essential role of redox regulation in health and disease. Christopher Horst Lillig is at the Institute for Medical Biochemistry and Molecular Biology at the University of Greifswald.