Academic Press Structure and Intrinsic Disorder in Enzymology (Foundations and Frontiers in Enzymology)

For more than a 100 years, the structure-function relationship has been a cornerstone of biology. However, it has recently emerged that intrinsic disorder is as important as well-defined structures for protein and enzyme function. Structure and Intrinsic Disorder in Enzymology offers a direct, yet comprehensive presentation of the fundamental concepts, characteristics, and functions of intrinsically disordered enzymes, along with valuable notes and technical insights powering new research in this emerging field. Here, more than twenty international experts examine protein flexibility and cryo-enzymology; hierarchies of intrinsic disorder; methods for measurement of disorder in proteins; bioinformatics tools for predictions of structure, disorder, and function; protein promiscuity; protein moonlighting; globular enzymes; intrinsic disorder and allosteric regulation; protein crowding; intrinsic disorder in post-translational modifications; protein misfolding and aggregation; myloids and prion-like domains; and phase separation in membrane-less cellular organelles, among other topics. Chapters also review methods for study, as well as evolving technology to support new research across academic, industrial, and pharmaceutical labs. Review Provides a thorough, practical overview of fundamental concepts, characteristics, and functions of intrinsically disordered enzymes, along with valuable notes, methods, and technical insights powering new research About the Author Dr. Munishwar Nath Gupta earned his PhD from Indian Institute of Science, Bengaluru, and completed post-doctoral positions at Massachusetts Institute of Technology (USA), University of Minnesota (USA), Lund University (Sweden), and University of Technology of Compiegne (France). He has taught chemistry, biochemistry, and biotechnology at the Indian Institute of Technology, Delhi, between 1975-2016. He was awarded the National Science Talent fellowship (India) and Fellowships of National Academy of Sciences and Indian National Science Academy. He has edited three books on thermostability of enzymes, non-aqueous enzymology and affinity-based separation methods. He was an Associate Editor of Biocatalysis and Biotransformation (Taylor and Francis) and the founding and former editor-in-chief of Sustainable Chemical Processes (Springer). He’s served on editorial boards of several national and international journals and acted as a consultant to Novozyme (Denmark), Dabur (India), and other international companies. Dr. Uversky received B.S. and M.S. degrees in Physics from Leningrad State University in Russia in 1986, then, completed Ph.D. and Doctor of Sciences (D.Sc.) degrees in Physics and Mathematics (field of study - Biophysics) at the Moscow Institute of Physics and Technology (1991) and the Institute Experimental and Theoretical Biophysics of the Russian Academy of Sciences (1998), respectively. In 1998, he moved to the University of California Santa Cruz to study protein folding, misfolding, protein conformation diseases, and protein intrinsic disorder phenomenon. In 2004, he was invited to join the Indiana University School of Medicine to primary work on the intrinsically disordered proteins, and since 2010 has been on faculty at the University of South Florida. He has authored over 850 scientific publications and edited several books and book series on protein structure, function, folding and misfolding. He is an editor of several scientific journals.