Woodhead Publishing Aptamers Engineered Nanocarriers for Cancer Therapy (Woodhead Publishing Series in Biomaterials)

Aptamers Engineered Nanocarriers for Cancer Therapy details the selection technologies, biological characteristics, and clinical uses of aptamer-based nano agents for cancer therapeutics. The book helps facilitate speedy solutions for some of the problems pertaining to the manufacture of nano-aptamers – such as toxicity, thermal stability, cost efficiency, tumor penetration and blood stability. Key chapters cover cell-SELEX technology for aptamer selection, mechanisms of multi-drug resistance of cancer, the relevance of aptamers as anticancer therapies, as well as the broad range of aptamer-functionalized nanostructures available. This book provides exciting insights into this relatively new approach to cancer therapeutics, and will be of interest to materials scientists, biomedical engineers, molecular biologists, biochemists and clinical scientists, with a focus on cancer therapy. Review Details the selection technologies, biological characteristics, and clinical uses of aptamer-based nano agents for cancer therapeutics From the Back Cover <p><i>Aptamers Engineered Nanocarriers for Cancer Therapy</i> details the selection technologies, biological characteristics, and clinical uses of aptamer-based nano agents for cancer therapeutics.</p> <p>Aptamers possess excellent specificity and high affinity to targets; when conjugated with functional nanomaterials, the specific binding ability and specialized properties of these nano-aptamers to cancer-related markers and cancer cells, may lead to early diagnosis of cancer and a better patient outlook. This book helps facilitate speedy solutions to some of the problems pertaining to the manufacture of nano-aptamers – such as toxicity, thermal stability, cost efficiency, tumour penetration and blood stability. Key chapters cover cell-SELEX technology for aptamer selection; mechanisms of multi-drug resistance of cancer and the relevance of aptamers as anticancer therapies, as well as detailing the broad range of aptamer-functionalized nanostructures available.</p> <p><i>Aptamers Engineered Nanocarriers for Cancer Therapy</i> provides an exciting insight into this relatively new approach to cancer therapeutics, and will be of interest to materials scientists, biomedical engineers, molecular biologists, biochemists and clinical scientists with a focus on cancer therapy.</p> About the Author Dr. Prashant Kesharwani is Assistant Professor of Pharmaceutics at the School of Pharmaceutical Education and Research, Jamia Hamdard University, New Delhi, India. He has published more than 150 articles in well reputed international journals and edited 10 international books. Dr. Kesharwani has received several awards, including the ‘Ramanujan Fellowship, DST, India-2017’, ‘Excellence Research Award 2014’, ‘Young Innovator Award (Gold medal) 2012’, ‘International Travel Award/Grant from DST (New Delhi) and INSA (CCSTDS, Chennai) 2012’, as well as receiving an ICMR Senior Research Fellowship (PhD) and AICTE Junior Research Fellowship (M. Pharm.). He has presented invited talks and presentations at prestigious conferences, supervised students/junior researchers, and actively participated in outreach and scientific dissemination for the service of the wider community. Dr. Kesharwani’s current research is focused on the development of nano-engineered drug delivery systems for various diseases.