Elsevier Functionalized Nanomaterials for the Management of Microbial Infection: A Strategy to Address Microbial Drug Resistance (Micro and Nano Technologies)

Functionalized Nanomaterials for the Management of Microbial Infection: A Strategy to Address Microbial Drug Resistance introduces the reader to the newly developing use of nanotechnology to combat microbial drug resistance. Excessive use of antibiotics and antimicrobial agents has produced an inexorable rise in antibiotic resistance in bacterial pathogens. The use of nanotechnology is currently the most promising strategy to overcome microbial drug resistance. This book shows how, due to their small size, nanoparticles can surmount existing drug resistance mechanisms, including decreased uptake and increased efflux of the drug from the microbial cell, biofilm formation, and intracellular bacteria. In particular, chapters cover the use of nanoparticles to raise intracellular antimicrobial levels, thus directly targeting sites of infection and packaging multiple antimicrobial agents onto a single nanoparticle. Provides the information users need to integrate antibacterial nanoparticles into future treatments Gives readers with backgrounds in nanotechnology, chemistry, and materials science an understanding of the main issues concerning microbial drug resistance and its challenges Includes real-life case studies that illustrates how functionalized nanomaterials are used to manage microbial infection Review A detailed examination of the use of nanotechnology as an effective strategy to overcome microbial drug resistance in bacterial pathogens From the Back Cover Tagline: A detailed examination of the use of nanotechnology as an effective strategy to overcome microbial drug resistance. Gives readers practicing biology, microbiology and clinicians the information they need to integrate antibacterial nanoparticles for future treatments. Gives readers with backgrounds in nanotechnology, chemistry and materials science and understanding of the main issues concerning microbial drug resistance and the challenges in this field. This cross-fertilization will generate new ideas to add to the field. The inclusion of real-life case studies illustrates to readers how functionalized nanomaterials are used to manage microbial infection. Functionalized Nanomaterials for the Management of Microbial Infection introduces the reader to the newly developing field of using nanotechnology to combat microbial drug resistance. Excessive use of antibiotics and antimicrobial agents has produced an inexorable rise in antibiotic resistance in bacterial pathogens. The use of nanotechnology is currently the most promising strategy to overcome microbial drug resistance. This book shows how, due to their small size, nanoparticles can surmount existing drug resistance mechanisms, including: decreased uptake and increased ef?ux of drug from the microbial cell, bio?lm formation, and intracellular bacteria. In particular, chapters cover use of nanoparticles to raise intracellular antimicrobial levels; directly targeting sites of infection and packaging multiple antimicrobial agents onto a single nanoparticle. Functionalized Nanomaterials for the Management of Microbial Infection is a valuable reference for researchers interested in the application of nanomaterials in pharmaceuticals, food science, environmental science and infectious diseases. ABOUT THE EDITORS Rabah Boukherroub is Director of Research at the CNRS at the Institute of Electronics, Microelectronics and Nanotechnology, University Lille 1, France. His research interests are in the area of synthesis of functional nanomaterials, surface chemistry, and photophysics of semiconductor/metal nanostructures with emphasis on biosensors, drug delivery, and development of new tools for studying molecular dynamics in vivo. He is a co-author of more than 370 research publications and 27 book chapters; he has 9 patents or patents pending. Djamel Drider is full professor of Microbiology at Lille 1 University Sciences and Technologies. D. Drider