Academic Press Novel Approaches to Colorectal Cancer (Volume 151) (Advances in Cancer Research, Volume 151)

Novel Approaches to Colorectal Cancer, Volume 151 in the Advances in Cancer Research series, is composed of 11 reviews covering state-of-the-art research relating to the etiology, diagnosis, prevention and treatment of colorectal cancer. The book's chapters were written by recognized experts in the field, and include sections on molecular biomarkers in diagnosis and therapy, the interplay of diet, lifestyle, and the microbiome, early-age onset disease, mutational signature analysis, challenges in early detection, immunotherapy, organoid technology, the role of epigenetic alterations, disparities in minority populations, field carcinogenesis, and cancer as an evolutionary process. Each of these topics provides novel insights and concepts on various aspects of the nature of colorectal cancer, offering new opportunities for the management of a major source of cancer incidence and mortality. Review This comprehensive guide provides invaluable information on the exciting and fast-moving field of cancer research From the Back Cover <i>Novel Approaches to Colorectal Cancer, Volume 151 </i>in the <i>Advances in Cancer Research</i> series is composed of 11 reviews covering state-of-the-art research relating to the etiology, diagnosis, prevention, and treatment of colorectal cancer.  The chapters were written by recognized experts in the field, and include: molecular biomarkers in diagnosis and therapy; the interplay of diet, lifestyle, and the microbiome; early-age onset disease; mutational signature analysis; challenges in early detection; immunotherapy; organoid technology; the role of epigenetic alterations; disparities in minority populations; field carcinogenesis; and cancer as an evolutionary process.  Each of these topics provides novel insights and concepts on various aspects of the nature of colorectal cancer, and offers new opportunities for management of a major source of cancer incidence and mortality. About the Author Dr. Berger is currently Director of Research & Outreach within the Colorectal Cancer Prevention Network at the University of South Carolina in Columbia, SC. He obtained a BA in Biology from the State University of NY at Buffalo in 1969, and a PhD in Biochemistry from Purdue University in 1974. In 1976. He began his career in cancer research at Roswell Park Cancer Institute in Buffalo, NY, where he was located until 1985 when he moved to the University of South Carolina. There, he was Professor in the Department of Biological Sciences until 2018, during which time he served as Department Chair (1996-2002) and was founding Director of the Center for Colon Cancer Research (2002-2018). For nearly 40 years, he ran a research laboratory focused on a variety of topics in mammalian molecular genetics, including colorectal cancer therapy and prevention. His efforts were generously supported by grants from the NIH, and resulted in over 130 articles in peer-reviewed scientific journals. Much of his research in colorectal cancer involved molecular mechanisms of resistance to chemotherapeutic agents. Most recently, Dr. Berger has carried out investigations involving the efficacy of colorectal cancer screening in the community setting, and has been actively engaged in community outreach efforts directed at increasing colorectal cancer awareness and screening, particularly within uninsured and medically underserved populations throughout the State of South Carolina. With the support of grants from foundations, as well as federal and state agencies, he has led the design and implementation of education and evidence-based screening programs across the State. He recently guest-edited a special focus issue of the journal COLORECTAL CANCER (Future Science Group, publisher) dedicated to early-onset colorectal cancer. Numerous graduate students and postdoctoral fellow trained in Dr. Berger’s laboratory, and went on to academic and/or corporate careers in scientific re