Academic Press Biomarkers in Kidney Transplantation: Clinical Aspects and Laboratory Determinations

Product Description Biomarkers in Kidney Transplantation: Clinical Aspects and Laboratory Determinations provides a focused study on traditional and emerging biomarkers to predict early rejection of kidney transplant supporting appropriate therapeutic interventions. Coverage includes predictive and diagnostic biomarkers for different types of rejections including biomarkers of acute, chronic/sub chronic rejection or clinical rejection, both the types T-cell mediated rejection, antibody mediated rejection or mixed rejection. Comparisons are provided for broad classification of pharmacokinetic versus pharmacodynamic biomarkers; and differentiation is shown between the susceptibility, diagnostic, predictive, prognostic and monitoring biomarkers. Coverage of the analytical aspects of biomarker measurement, the process of biomarker discovery and their clinical validation addresses both the clinical features of biomarkers as well as the pitfalls of determining such biomarkers in clinical laboratories. By combining all current markers known for kidney transplant in one collection, this easy to use reference is perfect for pathologists, clinical pharmacologists and clinical laboratory scientists as well as all physicians involved in organ transplantation including immunologists and transplant surgeons. Review Focused study on traditional and emerging biomarkers to predict early rejection of kidney transplant supporting appropriate therapeutic interventions From the Back Cover <i>Biomarkers in Kidney Transplantation: Clinical Aspects and Laboratory Determinations</i> provides a focused study on traditional and emerging biomarkers to predict early rejection of kidney transplant supporting appropriate therapeutic interventions. Coverage includes predictive and diagnostic biomarkers for different types of rejections including biomarkers of acute, chronic/sub chronic rejection or clinical rejection, both the types T-cell mediated rejection, antibody mediated rejection or mixed rejection. Comparisons are provided for broad classification of pharmacokinetic versus pharmacodynamic biomarkers; and differentiation is shown between the susceptibility, diagnostic, predictive, prognostic and monitoring biomarkers. Coverage of the analytical aspects of biomarker measurement, the process of biomarker discovery and their clinical validation addresses both the clinical features of biomarkers as well as the pitfalls of determining such biomarkers in clinical laboratories. By combining all current markers known for kidney transplant in one collection, this easy to use reference is perfect for pathologists, clinical pharmacologists and clinical laboratory scientists as well as all physicians involved in organ transplantation including immunologists and transplant surgeons. About the Author Smita Pattanaik received her MBBS from Utkal University, an MD in Pharmacology from PGIMER Chandigarh, DNB in Pharmacology from National Board of Examination New Delhi and DM in Clinical Pharmacology from PGIMER Chandigarh. Her current research focuses on concentrate on clinical pharmacology of immunosuppressant drugs, therapeutic drug monitoring and dose individualization (PK/PD) modeling and pharmacogenomics, clinical research methodology and biostatistics, clinical pharmacology of genitourinary system and bladder cancer chemotherapy. Ashish Sharma is a Professor and Head of the Institution Department of Research and Transplantation Surgey, Postgraduate Institute of Medical Education and Research. He has contributed more than 50 publications in national and international journals. He started laparoscopic donor nephrectomy at the Institute and has trained transplant surgeons from different part of India in this technique. His active involvement in promoting deceases donors and improving protocols for identification and counselling of brainstem dead donors has led to increased deceased organ donations. He also initiated simult