Academic Press Anti-Aging Pharmacology

Anti-Aging Pharmacology provides an overview of current research aimed at the pharmacological modulation of aging including a discussion of the growing number of novel drug classes with promising anti-aging potential. The aging process is the main risk factor for all chronic diseases affecting the elderly. With lifespans extending across the globe, these chronic diseases are placing a larger burden on individuals and health care systems. Therefore, slowing down the aging rate could be more effective in delaying aging-associated chronic disorders than combating them one by one, which is the conventional approach in a current disease-based pharmacological paradigm. Different drug classes shown to have pro-longevity properties in experimental models are being increasingly developed and investigated in pre-clinical and clinical trials to determine whether they have anti-aging potential as well. This book contains work of the world’s leading researchers in the field. It begins with the conceptual and methodological background of anti-aging pharmacology, explains the basic classes of anti-aging drugs, explores phytochemicals, and finally looks to outcomes of anti-aging developments and future directions. Anti-Aging Pharmacology will be of interest to a wide audience, ranging from pharmacologists, medicinal chemists, and academic researchers in gerontology, biomedical sciences, and those in medical practice. Review Explores the problem of human health span extension, discussing whether this can be achieved by pharmacological means From the Back Cover <i>Anti-Aging Pharmacology</i> provides an overview of current research aimed at the pharmacological modulation of aging including a discussion of the growing number of novel drug classes with promising anti-aging potential. The aging process is the main risk factor for all chronic diseases affecting the elderly. With lifespans extending across the globe, these chronic diseases are placing a larger burden on individuals and health care systems. Therefore, slowing down the aging rate could be more effective in delaying aging-associated chronic disorders than combating them one by one, which is the conventional approach in a current disease-based pharmacological paradigm. Different drug classes shown to have pro-longevity properties in experimental models are being increasingly developed and investigated in pre-clinical and clinical trials to determine whether they have anti-aging potential as well. This book contains work of the world’s leading researchers in the field. It begins with the conceptual and methodological background of anti-aging pharmacology, explains the basic classes of anti-aging drugs, explores phytochemicals, and finally looks to outcomes of anti-aging developments and future directions. Anti-Aging Pharmacology will be of interest to a wide audience, ranging from pharmacologists, medicinal chemists, and academic researchers in gerontology, biomedical sciences, and those in medical practice. About the Author Dr. Vaiserman is head of the Laboratory of Epigenetics at the Institute of Gerontology, where his research has focused on long-term health consequences of adverse conditions in early life, genetic and epigenetic mechanisms of age-associated diseases, telomere length in patients with age-related chronic diseases, and molecular mechanisms mediating lifespan in Drosophila. He earned his PhD from the Institute of Gerontology, Kiev, Ukraine in 2004. During the last 7 years, Dr. Vaiserman was Project Leader for several Ukrainian government sponsored research projects. Dr. Vaiserman is also a member of the editorial boards of the journals Biogerontology, Frontiers in Genetics of Aging, and Gerontology & Geriatric Research. To-date, he has published four book chapters, as well as 65 papers in peer reviewed journals.