Academic Press Tumor Microenvironment Regulation of Tumor Expansion

Tumor Microenvironment Regulation of Tumor Expansion is a practical guide to understand and perform research on tumor microenvironments, and to support related clinical decisions. Tumor progression is linked to an imbalance between positive and negative regulators, and mainly depends on the release of specific growth factors by inflammatory or neoplastic cells. Inflammatory infiltrate contributes to tumor progression and the metastatic process, and there are many reports of associations between tumor inflammatory infiltrate, progression, and prognosis. Understanding different contexts of organs is a key factor in improving treatment outcome, especially in new therapeutic treatments targeting components of the tumor microenvironment. This book is a valuable resource for cancer researchers, clinicians, graduate students, and scientists in many biomedical fields who are interested in the complex relationship between the tumor microenvironment and its context in specific organs. Review Presents major implications in the study of novel therapeutic cancer treatments that target the tumor microenvironment From the Back Cover Tumor Microenvironment Regulation of Tumor Expansion is a practical guide to understand and perform research on tumor microenvironment, and to support clinical decisions taking into consideration its specificities. Tumor progression is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors. Inflammatory infiltrate contributes to tumor progression and metastatic process, and there are many reports of associations between tumor inflammatory infiltrate, progression and prognosis. Understanding different contexts of organs is a key factor to improve outcome of treatments, especially new therapeutics targeting components of tumor microenvironment. This book is a valuable resource for cancer researchers, clinicians, graduate students and several members of biomedical field who are interested to learn about the complex relationship between tumor microenvironment and its context in specific organs. About the Author Domenico Ribatti is Professor of Human Anatomy, in the Department of Basic Biomedical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Italy. He was awarded his M.D. degree in 1981, with full marks. In 1983, he joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology. In 2008, he received the honoris causa degree in Medicine and Pharmacy form the University of Timisoara, Romania. He is the author of over 800 publications and 50 chapters, as well as a number of books for Elsevier/Academic Press including: Milestones in Immunology (2017) In Vivo Models to Study Angiogenesis (2017) Immunology in the Twentieth Century (2018) Tumor Vascularization (2020) Tumor Microenvironment Regulation of Tumor Expansion (2021) .