Academic Press Biomarkers of Hip Implant Function: Diagnostic Modalities to Prevent Chronic Periprosthetic Joint Infection and Implant Failure

Biomarkers of Hip Implant Function brings together established and potential new biomarkers, critically evaluating their clinical usefulness based on recent evidence. Researchers will benefit from a comprehensive view of the topic to identify underexplored areas. Orthopedic surgeons and general practitioners will use the book to monitor implant performance and facilitate management of their patients. Additionally, the work will benefit engineers and joint implant manufacturers to guide improvements in design. This book will also be of interest to regulators and policymakers by helping them update their guidelines on follow-ups for hip implant recipients. Nearly all orthopedic surgeons have implanted a cobalt-chromium hip and most general practitioners have at least one patient with cobalt-chromium implant on their books. The recent worldwide controversy surrounding metal-on-metal hips means that advice on how to manage patients with these implants is of great interest to these professionals. Hence, this book is a welcomed addition to the conversation. Review A comprehensive overview of the current evidence regarding the use of blood biomarkers to assess hip implant performance and toxicity risk From the Back Cover <p>Nearly all orthopaedic surgeons have implanted a cobalt-chromium hip and most general practitioners have at least one patient with cobalt-chromium implant on their books. The recent worldwide controversy surrounding metal-on-metal hips means that advice on how to manage patients with these implants is of great interest to these professionals. Specifically, they want to know if there are any diagnostic tests that could be performed to gain clues about implant performance and risk of local or systemic toxicity.</p> <p><i>Biomarkers of Hip Implant Function</i> aims to bring together all established and potential new biomarkers, and critically evaluate their clinical usefulness based on the most recent evidence available. Researchers will benefit from an updated, comprehensive view of the topic to identify underexplored areas. Orthopaedic surgeons and general practitioners will use the book to monitor implant performance and facilitate management of their patients. Additionally, the work will benefit engineers and joint implant manufacturers to guide improvements in implant design. The book will also be of interest to regulators and policymakers to update their guidelines on follow-up of hip implant recipients.</p> About the Author Ilona Swiatkowska is a final year doctoral candidate with 4 years of research experience. Her work has centered around the local and systemic adverse effects of cobalt, chromium and titanium in the setting of hip arthroplasty. The PhD project is supervised by Professor Alister Hart of the Royal National Orthopaedic Hospital, UK, whose research into blood cobalt and chromium levels in hip replacement patients has directly influenced the current MHRA guidelines concerning follow-up of patients with metal-on-metal hips. Ilona has published a comprehensive review on titanium as a biomarker of implant wear and defined an updated laboratory reference range for blood titanium associated with well-functioning titanium-based hip implants (manuscript currently under review at the Journal of Trace Metals in Medicine and Biology).