Academic Press ODE/PDE ?-synuclein Models for Parkinson's Disease

Product Description ODE/PDE Alpha-Synuclein Models for Parkinson's Disease discusses a mechanism for the evolution of Parkinson's Disease (PD) based on the dynamics of the protein a-synuclein, a monomer that has been implicated in this disease. Specifically, a-synuclein morphs and aggregates into a polymer that can interfere with functioning neurons and lead to neurodegenerative pathology. This book first demonstrates computer-based implementation of a prototype ODE/PDE model for the dynamics of the a-synuclein monomer and polymer, and then details the methodology for the numerical integration of ODE/PDE systems which can be applied to computer-based analyses of alternative models based on the reader's interest. This book facilitates immediate computer use for research without the necessity to first learn the basic concepts of numerical analysis for ODE/PDEs and programming algorithms Review Presents the first book to offer a software framework to study ODE/PDE prototype models for Parkinson’s Disease About the Author The R routines are available fromhttp://www.lehigh.edu/~wes1/pd_download Queries about the routines can be directedto wes1@lehigh.eduW.E. Schiesser is Emeritus McCann Professor of Chemical and Biomolecular Engineeringand Professor of Mathematics at Lehigh University. He holds a PhD from PrincetonUniversity and a ScD (hon) from the University of Mons, Belgium. His research is directedtoward numerical methods and associated software for ordinary, differential-algebraic andpartial differential equations (ODE/DAE/PDEs), and the development of mathematicalmodels based on ODE/DAE/PDEs. He is the author or coauthor of more than 14 books, andhis ODE/DAE/PDE computer routines have been accessed by some 5,000 colleges anduniversities, corporations and government agencies.