Academic Press Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications

Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications focuses on the regeneration of orthopedic tissue, drawing upon expertise from developmental biologists specializing in orthopedic tissues and tissue engineers who have used and applied developmental biology approaches. Musculoskeletal tissues have an inherently poor repair capacity, and thus biologically-based treatments that can recapitulate the native tissue properties are desirable. Cell- and tissue-based therapies are gaining ground, but basic principles still need to be addressed to ensure successful development of clinical treatments. Written as a source of information for practitioners and those with a nascent interest, it provides background information and state-of-the-art solutions and technologies. Recent developments in orthopedic tissue engineering have sought to recapitulate developmental processes for tissue repair and regeneration, and such developmental-biology based approaches are also likely to be extremely amenable for use with more primitive stem cells. Brings the fields of tissue engineering and developmental biology together to explore the potential for regenerative medicine-based research to contribute to enhanced clinical outcomes Initial chapters provide an outline of the development of the musculoskeletal system in general, and later chapters focus on specific tissues Addresses the effect of mechanical forces on the musculoskeletal system during development and the relevance of these processes to tissue engineering Discusses the role of genes in the development of musculoskeletal tissues and their potential use in tissue engineering Describes how developmental biology is being used to influence and guide tissue engineering approaches for cartilage, bone, disc, and tendon repair Review Brings orthopedic tissue engineering and developmental biological principles together to create enhanced clinical results About the Author Since 2009 Prof. Martin Stoddart has been working as a Principal Scientist at the AO Research Institute Davos (ARI), where he is responsible for the Stem Cell Focus Area. He completed his bachelor studies in Biology at the University of Aberystwyth in 1995. He then spent a year in Davos at ARI where he completed his M.Phil in Cartilage Biology. Between 1996-2000 he carried out his doctoral thesis at the University of Nottingham in the field of Cancer Angiogenesis. He then returned to Switzerland to work in the Laboratory for experimental cartilage research in Zürich, initially as Post-Doc and between 2003-2005 as Group Head. During that time, he took a 6 month sabbatical at the Centre for Molecular Orthopeadics, Harvard Medical School, Brigham and Womens Hospital, Boston, to learn viral gene transfer techniques. In 2005 he returned to ARI, where he is the Stem Cell focus area leader. He is a lecturer at the ETH Zürich and in 2015 he was awarded an Honorary Professorship from the Medical Faculty, Albert-Ludwigs University, Freiburg, Germany. In 2016 he was awarded an Honorary Professorship at the Institute for Science & Technology in Medicine University of Keele, UK. He is a Fellow of the Royal Society of Biology and a Fellow member of the International Cartilage Repair Society. His main focus is the use of autologous stem cells and gene transfer for the repair of musculoskeletal tissues using a cell therapy approach. To this aim he investigates novel cell identification and isolation methods. His research interests include the mechano-regulation of stem cell fate, in particular chondrogenic differentiation. This has led to advances in regenerative rehabilitation and the discovery of novel clinically relevant biomarkers and targets. He is also interested in the mechanisms by which stem cells direct cell fate and interact with endogenous cells to effect a repair. He is the author of over 80 scientific papers, 10 book chapters and is the edito