Academic Press Molecular Targets in Protein Misfolding and Neurodegenerative Disease: Focus on Tau, Alzheimer's Disease, and Other Tauopathies

Aimed at "drug discoverers" - i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc. * Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases* Provides a "drug discovery application oriented perspective, evaluating targets and candidates for their overall therapeutic potential* Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development* Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area* Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets