Academic Press Biased Signaling in Physiology, Pharmacology and Therapeutics,

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective. Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling Review "...markedly contributes to our understanding of biochemical and cellular mechanisms of diseases that should result in improved therapies for treating diseases. I highly recommend this book to any scientists working in the field of receptor biology. Four Stars - Score: 91"- Doody's Review The first book to cover biased signaling across several receptor types, this unique resource offers real-world examples and valuable insight on how to use this data to understand complex pharmacology About the Author Dr. Brian Arey received his bachelor’s degree in biology from St. Louis University where as an undergraduate he performed research on estrogen and progesterone receptors and their interactions with chromatin. Brian then moved to Florida State University where he received both Master’s and Doctorate degrees studying neuroendocrine physiology with Dr. Marc Freeman. His theses described the discovery of a novel underlying circadian rhythm of neurotransmitters regulating pituitary prolactin secretion. Pharmacological and unique physiological experiments led to the identification of the key neurotransmitters systems involved thus providing a working model of the neurotransmitter reflex. This work ultimately became the foundation for understanding regulation of prolactin secretion in rats. At this time, Dr. Arey also collaborated with fellow students in understanding the biphasic signaling of dopamine to regulate prolactin secretion in vivo. In 1992, his work in graduate school led to an NIH Postdoctoral Fellowship in the NIH Center for Reproductive Sciences at Northwestern University, where he studied the expression and signaling mechanisms of the mouse and rat prolactin receptors. He then joined the Women’s Health Research Institute at Wyeth-Ayerst Research as an independent investigator. While at Wyeth in the mid-90’s, Dr. Arey collaborated to develop some of the first described allosteric agonists