Academic Press Neuroprotective Agents and Cerebral Ischaemia (Volume 40) (International Review of Neurobiology, Volume 40)

Since 1959, International Review of Neurobiology has been a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. This important serial is now being combined with Neuroscience Perspectives and Methods in Neurosciences. This combination results in a series that reaches a wider audience and publishes a greater number of thematic volumes. Stroke is the third major cause of death in the western world, and recent data provide hope that treatments may soon be available. Written by world experts on the mechanisms involved in neurodegeneration, Neuroprotective Agents and Cerebral Ischaemia presents an up-to-date review of current research and developing therapies. This book is essential reading for all clinicians and researchers searching for neuroprotective drugs. Describes the mechanisms involved in cell death and the biochemical changes occurring during an ischaemic episode Presents the different factors affecting the neurodegenerative process and how compounds acting on these systems may lead to novel neuroprotective agents Reviews in vitro and in vivo models of stroke and the activity of putative neuroprotective drugs Discusses the application of preclinical data to formulate approaches to a clinical problem Provides detailed reviews of both completed clinical trials and those currently underway Review "In balance, I recommend this book as a superior volume, whose high 'power-to-weight ratio,' readability, and availability in paperback make it attractive for personal use." --TRENDS IN NEUROSCIENCES Synopsis Since 1959, "International Review of Neurobiology" has been a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. This important serial is now being combined with "Neuroscience Perspective and Methods in Neurosciences". This combination results in a series that reaches a wider audience and publishes a greater number of thematic volumes. Its key features include: description of the mechanisms involved in cell death and the biochemical changes occurring during an ischaemic episode; chapters on the different factors affecting the neurodegenerative process and how compounds acting on these systems may lead to novel neuroprotective agents; reviews of in vitro and in vivo models of stroke and the activity of putative neuroprotective drugs; discussion of the application of pre-clinical data to the clinical problem; and detailed reviews of both completed clinical trials and those currently underway. From the Back Cover Stroke is the third major cause of death in the western world, and recent data are providing hope that treatments may soon be available. This book, written by world experts on the mechanisms involved in neurodegeneration, provides an up to date review of current research and developing therapies. Features of Neuroprotective Agents and Cerebral Ischaemia include: * Description of the mechanisms involved in cell death and the biochemical changes occurring during an ischaemic episode * Chapters on the different factors affecting the neurodegenerative process and how compounds acting on these systems may lead to novel neuroprotective agents * Reviews of in vitro and in vivo models of stroke and the activity of putative neuroprotective drugs * Discussion of the application of pre-clinical data to the clinical problem * Detailed reviews of both completed clinical trials and those currently underway This book will be essential reading for all clinicians and researchers searching for neuroprotective drugs. About the Author Alan Cross was at the MRC Clinical Research Centre, London, followed by two years as a lecturer in the Department of Physiology, University of Manchester. In 1980 he became Head of Pharmacology at the Aston Neuroscience Research Unit.