Elsevier Alpha-glucosidase Inhibitors: Clinically Promising Candidates for Anti-diabetic Drug Discovery

Alpha-glucosidase Inhibitors: Clinically Promising Candidates for Anti-diabetic Drug Discovery presents information that researchers can use to address a whole host of promising leads for the development of novel, oral, anti-diabetic drugs with improved efficacy and fewer side effects. Beginning with a discussion of the huge potential of a -glucosidase inhibitor leads and adaptations, and highlighting their importance within the field of anti-diabetic drug discovery, the book provides chemical structures, detailed background information and in vivo and in vitro biological activity data, and more economical adaptations of these structures. Drawing on the author's expert research in the field, this book highlights promising leads for development and helps researchers select the most appropriate inhibitors for their own work. It is a useful tool not only for anti-diabetic drug development researchers, but also for those whose research may be enhanced by an understanding of a -glucosidase inhibitor chemistry and activity. Review A guide to the chemistry of a-glucosidase inhibitors for the development of enhanced anti-diabetic drugs From the Back Cover Over 400 million people worldwide have been diagnosed with diabetes and the numbers continue to rise, highlighting the increasing necessity for new and improved treatment options. a -glucosidase inhibitors, currently used in diabetes treatment, offer a wide chemical diversity, making them good candidates for further development. However, those in current use are marred by efficacy problems and unwanted side effects. Promising a-glucosidase Inhibitors For Development Into Oral Anti-diabetic Drugs aims to support researchers in addressing these issues, highlighting a whole host of promising leads for development into novel oral anti-diabetic drugs with improved efficacy and fewer side effects. Beginning with a discussion of the huge potential of a -glucosidase inhibitor leads and adaptations, highlighting their importance and putting them into context within the field of anti-diabetic drug discovery, the book goes on to review a whole range of natural and synthetic a -glucosidase inhibitors. By providing chemical structures, detailed background information and in vivo and in vitro biological activity data, the book facilitates faster, more economical adaptation of these structures for development into oral anti-diabetic drugs. Drawing on the authors expert research in the field, Promising a-glucosidase Inhibitors For Development Into Oral Anti-diabetic Drugs highlights promising leads for development and helps researchers select the most appropriate inhibitors for their own work, making it a useful tool not only for anti-diabetic drug development researchers, but all those whose research may be enhanced by an understanding of a -glucosidase inhibitor chemistry and activity. About the Author Usman Ghani is Assistant Professor of Biochemistry at King Saud University (KSU), Saudi Arabia. After gaining experience as a Chemist and Researcher in Pakistan, he completed his PhD at the University of Alberta, Canada, and took up a Postdoctoral Fellowship there before moving to KSU in 2005. He has been awarded numerous research grants and has published 23 papers to date. Prof Ghani’s current research involves screening and identification of clinically important enzyme inhibitors and studies on their mechanism of inhibition. His team has identified a number of synthetic and natural inhibitors of tyrosinase and alpha-glucosidase enzymes that may become potential candidates for development into drugs for the treatment of hyperpigmentation and diabetes respectively.