£112.42

Woodhead Publishing A Practical Guide to Rational Drug Design

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Last 628 days • 628 data points (No recent data available)

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£124.16 £110.05 £113.13 £116.21 £119.28 £122.36 £125.44 09 June 2024 12 November 2024 18 April 2025 22 September 2025 26 February 2026

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63 days · current 53 days 344 days 129 days 39 days 0 86 172 258 344 £111-114 £114-116 £116-119 £119-122 £122-124 Days at Price

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Most common range: £116-119 (344 days, 54.8%)

Price range: £111 - £124

Price levels: 5 price ranges over 628 days

Description

This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors’ active compounds or from natural ligands of the targets; how to springboard from competitors’ SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes. Discusses various tactics applicable to daily drug design Readers can download the materials used in the book, including structures, scripts, raw data, protocols, and codes, making this book suitable resource for short courses or workshops Offers a unique viewpoint on drug discovery research due to the author’s cross-discipline education background Explores the author’s rich experiences in both pharmaceutical and academic settings

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