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Wiley Bioisosteres in Medicinal Chemistry (Methods & Principles in Medicinal Chemistry)

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Description

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

Key Features

Bioisosteres in Medicinal Chemistry Methods and Principles in Medicinal Chemistry, 54, Vol. 54

Product type: ABIS BOOK

Color: White

Product Specifications

Brand
Wiley
Format
hardcover
Domain
Amazon UK
Release Date
22 August 2012
Listed Since
09 December 2010

Barcode

No barcode data available

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